San Ming Wang
University of Nebraska Medical Center, USA
Title: Impact of variation in regulatory region on gene expression
Biography
Biography: San Ming Wang
Abstract
Promoter is the regulatory part of a gene. In promoters, the interactions between cis-regulatory elements, e.g., transcription-factor binding sites (TFBS), and trans-regulatory elements, e.g., transcription factors (TFs), spatially and temporally regulate gene expression to ensure homeostasis of biological functions. Alterations in promoter sequences can change cis-trans interactions resulting in modified gene expression, impacting downstream biological processes, and leading to the development of disease. In this workshop, I will give an introduction on the topic, show the data from my breast cancer studies, and then have a round table discussion/presentation for attendees to address the issue covering normal gene expression regulation, evolution conservation, alternation in disease, etc.
