Biography
Biography: Yan Li
Abstract
HumanN-myc downstream regulated gene 2(NDRG2) has been proved to be a multifunctional protein associated with cell proliferation, differentiation, transmembrane transportation and stress response. The expression of NDRG2 is transcriptionally regulated by Myc, TNFαIGF-1, hypoxia, DNA damage and many hormones including dexamethasone, insulin, androgens and aldosterone. In this study, we analyzed the promoter region flanking 5’ of NDRG2 and found a potential ERE (estrogen response element). Moreover, we revealed that estrogencan up-regulate the expression of NDRG2 inboth dose and time-dependent manners. In addition, we demonstrated that ERβ but not ERα, bound specifically to the ERE at position of -1455 to -1131 bp of NDRG2 promoter and trans-activated NDRG2 promoter. These data mean that estrogen as an important circulating hormone also plays a regulative role in NDRG2 expression. In our previous studies we found that NDRG2 interacts with β1-subunit of Na+/K+-ATPase and is involved in estrogen-mediated Na+ and Cl− transport in some epithelial cells. Therefore, characterization of the novel estrogen/NDRG2/Na+/K+-ATPase β1 regulation pathway will broaden the understanding of the regulatory role of estrogen on Na+/K+-ATPase and distribution of this pathway may potentially provide a basis for the intervention of isohydria and internal environment homeostasis in some pathological conditions.
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