Epigenetics

Epigenetic modulation of gene expression is responsible for tissue specific and temporal changes across growth and development. The most widely studied of these epigenetic modifications is DNA methylation of 5-methylcytosine at CpG dinucleotides and histone modification. This DNA methylation can be caused by small factors like smoking tobaccos. Aberrations of DNA methylation are associated with a range of diseases, including imprinting disorders and cancer. Recent advances in technologies have made it possible to study the epigenetic changes associated with these diseases using robust genome-wide technologies including the Infinium HumanMethylation450 BeadChip (henceforward denoted the 450 k array; These intensities are then used to calculate DNA methylation levels, with advantageous throughput, cost, coverage and technical consistency. Gene silencing is also used for epigenetic regulation of gene expression. To study the modification on the genetic material of the cell called epigenome, Epigenomics comes into action. For all aspects of epigenetic principles and mechanisms in relation to human disease like diabetes and cancer, diagnosis and therapy Clinical Epigenetics is taken into consideration. It focuses on Clinical trials and research in disease model organisms. Currently, Pfizer is a major company carrying its research and development on Epigenetics.

Ulrich Mahlknecht is currently a Professor of medicine at the University of Heidelberg, and Head of the Department of Hematology/Oncology at St. Lukas Clinic in Solingen, Germany. His research focuses on novel targeted immunological and epigenetic concepts in the treatment of solid tumors and hematological malignancies.

 

  • DNA Methylation
  • Histone Modification
  • Gene Silencing
  • Epigenomics
  • Clinical Epigenetics

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