ConferenceSeries Ltd invites all the participants from all over the world to attend the “2^nd International Conference on Transcriptomics” during September 12-14, 2016 at Philadelphia, USA which includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions.

Transcriptomics-2016 mainly emphasizes on the topics like RNA-Seq, Oncogenomics, Cancer Transcriptomics, RNA editing, RNA interferance, Non-coding RNA, DNA Methylation, DNA Sequence, Molecular Cell, Molecular Cell Biology, Transcriptomics related with Replication and Reproduction, Plant transcriptomics, Bacterial transcriptomics, Viral Transcriptomics, Fungal Transcriptome, Riboswitch, trp operon, Neurological Disorders, and Transcriptional Attenuation.

Track Description:

Track 1: Transcriptome Analysis & Gene Expression

For an International conference on Transcriptomics, an overview on Transcriptome analysis and Gene Expression is the first and the essential most topics to be discussed. While going in depth of the subject, it is necessary to understand Transcriptome as Key Players in Gene Expression. For that we should know the basics knowledge of how the central dogma works. This can be achieved by gaining proper knowledge about functioning of mRNA, tRNA and rRNA. Gene expression analysis experiments can focus on a subset of relevant target genes. The location of gene and relative distances between genes on a chromosome can be determined through Sequence mapping. Even in the absence of the reference genome, transcriptome can be created using  de novo Transcriptome assembly method. Globally around thousands of Universities and institutes are carrying research on gene expression and transcriptome analysis. Being specific are the University of Leeds, Case Western Reserve University, Arizona State University, Tempe. Institutes like The Genome Institute – St. Louis, Missouri and NIH - National Human Genome Research Institute are working tremendously towards the same where researchers are having a database of over 40,000 gene sequences that they can use for this purpose.

Relevant Conferences:

2^nd International Conference on Transcriptomics, September 12-14, Philadelphia, USA; Clinical and Molecular Genetics Conference November 28-30, 2016 Chicago, USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA; Genetic and Protein Engineering Conference, November 14-16, 2016 Atlanta, USA; Genetic Counselling and Genomic Medicine Conference August 11-12, 2016 Birmingham, UK; Post-Transcriptional Gene Regulation(GRS), July 09-10, 2016 Vermont, USA; Basic Epigenetic Mechanisms in Cancer, November 8-11, 2015 Berlin, Germany, Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 2:  RNA Editing & Interference: Interplay

RNA editing is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within a RNA molecule after it has been generated by RNA polymerase. RNA editing has been observed in the RNA sequence and analysis of viruses, archaea and prokaryotes. RNA editing occurs in the cell nucleus and cytosol, as well as within mitochondria and plastids. In vertebrates, editing is rare and usually consists of a small number of changes to the sequence of affected molecules. Two types of small ribonucleic acid (RNA) molecules – microRNA (miRNA) and small interfering RNA (siRNA) – are central to RNA interference. The study of RNA interference incudes its cellular mechanisms, variation among organisms, biological functions like immunity, down regulation of genes, up regulation of genes and its applications in Gene knockdown, Structural and Functional genomics, medicine and biotechnology. The University of Albany situated at New York is rigorously involved towards all the novel research on RNA. The RNA Institute maintained by Paul Agris (University at Albany) is the best known platform for carrying out RNA analysis. Added to that, The RNA Society formed in 1993 facilitates sharing and dissemination of experimental results and emerging concepts in ribonucleic acid research.

Relevant Conferences:

International Conference on Nucleic Acids, August 04-05, 2016 New Orleans, USA; World Congress on Amino Acids and Proteins, December 08-09, 2016 Texas, USA; International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia, USA; 2^nd International Conference on Transcriptomics  September 12-14, 2016 Philadelphia, Pennysylvania USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA; EMBL Conference - Transcription and Chromatin, August 27-30, 2016 Heidelberg, Germany;  Chromatin Structure & Function, May 22-27, 2016 Les Diablerets, Switzerland;  Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 3: Exploring Transcriptome

While exploring the complexity of the Transcriptome, the basic protocol of the identification of long stress-induced non-coding transcripts is followed. Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but are not translated into proteins. Functional Impact of Non-Coding RNA (ncRNA) involves regulation of gene expression at the transcriptional and post-transcriptional level. Those ncRNAs that appear to be involved in epigenetic processes can be divided into two main groups; the short ncRNAs (<30 nts) and the long ncRNAs (>200 nts). Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a potentially new and crucial layer of biological regulation. Long noncoding RNA (lncRNAs) biochemically resemble mRNAs posited by Jacob and Monod, yet do not template protein synthesis. Rather, lncRNAs functioning as RNA genes to orchestrate genetic regulatory outputs. Today, lncRNA transcripts have emerged as a cryptic, but critical layer in the genetic regulatory code. It has been implicated in a range of developmental processes and diseases in which Long ncRNAs target proteins to specific genomic loci to affect transcription patterns. It also modulates the activity of protein-binding partners. They also act as precursors for small RNAs. Analysis of the Transcriptome on neurological basis can be done under the title of profiling microRNAs and circular RNAs in brain. Here we can find out how the genomic basis is responsible for the behavioural changes through neurological basis. Even this phenomenon can be controlled through Regulation of Transcriptional Heterogeneity. The basic strategy behind the all this mechanism comes from the molecular level which contain Chromatin and Histone Protein.

John L. Rinn is the Alvin and Esta Star Associate professor of Stem Cell and Regenerative Biology at Harvard University and Medical School and Senior Associate Member of the Broad Institute. Our research aims to understand the role of long non-coding RNAs (lncRNAs) in establishing the distinct epigenetic states of adult and embryonic cells and their misregulation in diseases such as cancer.

Relevant Conferences:

International Conference on Nucleic Acids, August 04-05, 2016 New Orleans, USA; World Congress on Amino Acids and Proteins, December 08-09, 2016 Texas, USA; ; International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia, USA; 2^nd International Conference on Transcriptomics  September 12-14, 2016 Philadelphia, Pennysylvania USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA ; EMBL Conference - Transcription and Chromatin, August 27-30, 2016 Heidelberg, Germany;  Chromatin Structure & Function, May 22-27, 2016 Les Diablerets, Switzerland;  Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 4: NGS Technologies

Next Generation Sequencing (NGS) Technologies enable a wide variety of methods, allowing researchers to ask virtually any question related to genome, Transcriptome,  or epigenome of any organism. Sequencing methods differ primarily by how the DNA or RNA samples are obtained and by the data analysis used. The numbers of methods is constantly growing. The most common are small RNA-Seq: Whole Transcriptome Shotgun Sequencing, Exome Sequencing, De Novo Full-Length Transcriptome data Analysis and Hybrid Sequencing Approach. Various NGS platforms in the market such as Illumina, SOLiD, and Roche, offer unprecedented ability to apply massively parallel sequencing of transcriptomics (RNA) and genomic (DNA) samples to understand disease and health. The enormous Differential Splicing and RNA Sequencing and analysis Data pose a fundamental problem of management and analysis. Various data analysis solutions eliminate the next-generation sequencing data management. ABRF Next-Generation Sequencing (ABRF-NGS) is the most effective technique for accurate sequencing data. For Ribonucleic acid, Single-cell RNA sequencing (scRNA-seq) is carried out which examines the RNA sequence information from individual cells with optimized next generation sequencing (NGS) technologies, providing a higher resolution of cellular differences and a better understanding of the function of an individual cell in the context of its microenvironment.

Relevant Conferences:

International Conference on Nucleic Acids, August 04-05, 2016 New Orleans, USA; World Congress on Amino Acids and Proteins, December 08-09, 2016 Texas, USA; ; International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia, USA; 2^nd International Conference on Transcriptomics  September 12-14, 2016 Philadelphia, Pennysylvania USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA ; EMBL Conference - Transcription and Chromatin, August 27-30, 2016 Heidelberg, Germany;  Chromatin Structure & Function, May 22-27, 2016 Les Diablerets, Switzerland;  Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 5: Diagnosis & Applications of RNA-Seq

Disease interrogation & clinical applications of RNA-Seq involves different methods that are required for gene expression analysis. Like, we can find out the Alternative Protein-Coding Transcripts in Prostate Cancer to interrogate its nature and occurrence. Targeted RNA sequencing and analysis is a highly accurate and specific method for measuring expression of transcripts of interest, offering both quantitative and qualitative information. This allows for differential expression analysis, as well as allele-specific expression measurement and verification of the presence of fusion genes. The ability to obtain a complete picture of Intergenic Disease-Associated Regions provides clear understanding of how the underlying genome is converted into the functional proteins, allowing for clinical utility in patient classification, diagnosis, and individualized treatment. To understand which coding and non-coding RNAs are transcribed in the diseased cell, deciphering the Diseased Transcriptome by RNA-Seq and qPCR can be done. The Northwestern University Feinberg School of Medicine has a special unit called Centre for Genetic Medicine where bioinformatics analysis of a RNA-seq is performed. Other universities include The Rockefeller University and University of Bristol, UK.

Relevant Conferences:

International Conference on Nucleic Acids, August 04-05, 2016 New Orleans, USA; World Congress on Amino Acids and Proteins, December 08-09, 2016 Texas, USA; ; International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia, USA; 2^nd International Conference on Transcriptomics  September 12-14, 2016 Philadelphia, Pennysylvania USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA ; EMBL Conference - Transcription and Chromatin, August 27-30, 2016 Heidelberg, Germany;  Chromatin Structure & Function, May 22-27, 2016 Les Diablerets, Switzerland;  Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 6: Human Transcriptomics

Human Transcriptome study is a part of Human Genome Project which is an international scientific research project with the goal of determining the sequence of chemical base pairs which make up human Transcriptome and of identifying and mapping all of the genes of the human genome from both a physical and functional standpoint.

Relevant Conferences:

Human Genetics Congress, October 31-November 02, 2016 Valencia, Spain; Genetic Counselling and Genomic Medicine Conference August 11-12, 2016 Birmingham, UK; Molecular and Cancer Biomarker Conference September 15-17, 2016 Berlin, Germany; Clinical and Molecular Genetics Conference November 28-30, 2016 Chicago, USA; International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia, USA; The European Human Genetics Conference, May 21-24, 2016 Barcelona, Spain; Conference on Human Genome Variation, May 31-June 04, 2016, Uppsala, Sweden.  Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 7: Transcriptomics & Proteomics in Microorganisms

Transcriptomics and Proteomics of Microorganisms describe the roles of transcriptome and proteome in all the microorganisms like bacteria, fungi and viruses. To understand the phenomenon behind a viral infection, the proteins involved and their expression should be known which can be discovered by Transcriptomic and Proteomic Profiling of Viruses. The second section involves fungi and their metabolic changes. A wide variety of fungi have demonstrated the ability to colonize surfaces and form biofilms. This is a major concern requiring knowledge of the biofilm mechanisms which can be fulfilled by the transcriptomic and proteomic analysis of bacterial and fungal biofilms. To analyse complex bacterial flora, Large scale Analysis of Complex Bacterial Communities is performed. This large-scale cloning and sequencing of 16Srna involved in protein expression.

The National Science Foundation Offers awards and funding opportunities in the research and thus so named where discoveries begin.

Relevant Conferences:

4^th Bacteriology and Infectious disease Conference May 16-18, 2016 San Antonio, USA; 6^th Clinical Microbiology Conference, October 20-22, 2016 Rome, Italy; 5^th Microbial Phsiology and Genomics Conference, September 29-30, 2016 London, UK; 2^nd Applied Microbiology Conference , November 10-12, 2016 Istanbul, Turkey; Infectious Diseases & Diagnostic Microbiology Conference ,October 03-05, 2016 Vancouver, Canada; XVII International Congress on Molecular Plant-Microbe Interactions, July 17-21, 2016, Portland, USA; Microbe 2016, September 23-25, 2016, Sheffield, UK; The Molecular biology Society of Japan Annual Meeting, November 29-December 2, 2016 Yokohama, Japan:  Genetic Society of America , July 13-17, 2016, in Orlando, Florida ; American Society of Human Genetics, October 18-22 , 2016 Vancouver, Canada.

Track 8: Transcriptomics & Proteomics in Plants

Data emanating from RNA Sequencing and analysis studies have greatly improved the coverage of Transcriptomics and Proteomics of Plants. This technology further compounded transcriptome analysis by making it possible to identify differentially spliced transcripts etc. In the research, either microarray or RNAseq based datasets is used for Transcriptome Analysis of Agricultural Plants. These datasets are stored as Transcriptome sequence Databases. To clarify the phylogeny of green plants, sequences from the plastid genome are used which is termed as Plant Phylogenomics

Proteomics of Plant Study has been a major boon for many companies, to name a few being Accelrys, ActivX Biosciences, Beyond Genomics, Biomax Informatics AG and Biovation. The research as gained a lot of applications in industry have gained up as a major study in too in top schools as of International Plant Proteomics Organization, Murdoch University, University of Nottingham, University of Salford Manchester and University Of Nebraska–Lincoln.

Relevant Conferences:

Plant Physiology Conference, June 09-10, 2016 Dallas, USA; 2^nd Global Summit on Plant Science October 31-November 02, 2016 Baltimore, USA; 2^nd International Conference on Transcriptomics  September 12-14, 2016 Philadelphia, Pennysylvania USA; 7^th International Conference on Bioinformatics  October 24-25, 2016 Rome, International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia, USA ; Plant Biology 2016, July 07-13, 2016 Austin, USA; Plant Genomes & Biotechnology: From Genes to Networks, December 02-05, 2016 Cold Spring Harbor, USA; International Congress on Molecular Plant-Microbe Interactions, July 17-21, 2016, Portland, USA;  Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 9: Single Cell Transcriptomics

Single-cell protein (SCP) typically refers to sources of mixed protein extracted from pure or mixed cultures of algae, yeasts, fungi  or bacteria (grown on agricultural wastes) used as a substitute for protein-rich foods, in human and animal feeds. The study of this single cell on molecular basis is done by Single-cell Genomics which involves different tools and techniques. Single cell sequencing involves Transcription of Cells, after which it examines the sequence information from individual cells with optimized next generation sequencing (NGS) technologies like Single-cell RNA Sequencing(scRNA-seq), providing a higher resolution of cellular differences and a better understanding of the function of an individual cell in the context of its microenvironment.

Relevant Conferences:

2^nd International Conference on Transcriptomics, September 12-14, Philadelphia, USA; Clinical and Molecular Genetics Conference November 28-30, 2016 Chicago, USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA; Genetic and Protein Engineering Conference, November 14-16, 2016 Atlanta, USA; Genetic Counselling and Genomic Medicine Conference August 11-12, 2016 Birmingham, UK; Post-Transcriptional Gene Regulation(GRS), July 09-10, 2016 Vermont, USA; Basic Epigenetic Mechanisms in Cancer, November 8-11, 2015 Berlin, Germany, Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 10: Relation with OMICS Sciences

Genomics, Proteomics and Bioinformatics are all from the field of OMICS sciences, which revolve around Transcriptomics. Disruptions or changes at any step of gene expression are responsible for many genetic diseases. Through the use of Genome Analysis and Microarrays scientists can determine – in a single experiment – the expression levels of hundreds or thousands of genes within a cell. All these genome sequence data can be recalled Big Data Mining. Other field of genomics related to sequence analysis is Functional Genomics, Computational Genetics, Comparative Genomics, Translational Genomics, and Evolutionary Genomics.

Molecular evidence from a sequence-based application is a main agenda in Plant Genomics and Microbial Genomics. For a higher resolution of cellular differences and a better understanding of the function of an individual cell in the context of its microenvironment, Single Cell Genome sequencing is done which examines the sequence information from individual cells with optimized next generation sequencing (NGS) technologies. For more information about the products (proteins) of these cells, it is mandatory to understand the mechanism involved in their transcription and translation. In that case Proteomics of Transcription Machinery, proving itself helpful in explaining the expression of proteins by through ribosome in a Single cell. Coming to the Bioinformatics, the major breakthrough involves Drug designing and Drug Discovery, making the entire process more fast at quite low cost.

Genomic labs have the fastest growing market with nearly 250 universities concentrating on its research majorly to be named Whitetail Genetic Research Institute, Stanford University, National Human Genome Research Institute. Major companies concentrating on the research are Affymetrix, Applied Biosystems, Foster City, and Genentech etc.  Drug Discovery research has the major growing market with applications in pharmaceuticals and medicine and thus major companies like Bristol-Myers Squibb Company, Isis Pharmaceuticals, Inc. , Merck & Co. Inc. and Johnson & Johnson focusing on the growing industry.

Relevant Conferences:

6^th Genomics and Pharmacogenomics Conference, September 12-14, 2016 Berlin, Germany;; 6^th International Conference on Bioinformatics  October 24-15, 2016 Rome, Italy; 5^th International Conference on Metabolomics May 16-18, 2016, Osaka, Japan; International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia, USA; Genetic and Protein Engineering Conference, November 14-16, 2016 Atlanta, USA ; Conference on Genomic Instability , July 23-24, 2016, Hong Kong, China; X Annual Congress of the European Proteomics Association, June 21-25, 2016 Istanbul, Turkey;  Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 11: Expression Profiling

Gene expression profiling simultaneously compares the expression levels of many genes between two or more sample types. This analysis can help scientists identify the molecular basis for phenotypic differences and select gene expression targets for in-depth study using other technologies. Gene expression profiling provides valuable insight into the role of differential gene expression in normal biological and disease processes. There are many techniques used for gene expression profiling. One of the major techniques for expression profiling includes Measuring Relative Activity by SAGE and Super SAGE, where SAGE stands for serial analysis of gene expression technology for the analysis of expressed genes.  The other technique includes Genome annotation which provides functional and other information, for example the location of each gene within a particular chromosome. Some functional annotations are more reliable than others; some are absent. Gene annotation databases change regularly, and various databases refer to the same protein by different names, reflecting a changing understanding of protein function. Having identified some set of regulated genes, the next step in expression profiling involves looking for patterns within the regulated set for categorizing regulated genes. This can be done by finding similarities between the functioning of the proteins produced from different cell. Further categorization is done on the basis of relationship between two genes and their products by finding patterns among regulated genes. This is analysed by the fact that what these regulated genes actually are and what they do. Compared to Proteomics, the human genome contains on the order of 25,000 genes which work in concert to produce on the order of 1,000,000 distinct proteins. Knowledge of the precise proteins a cell makes, is more relevant than knowing how much messenger RNA is made from each gene, gene expression profiling provides the most global picture possible in a single experiment.

Gene Expression profiling has a growing research being utilized by major companies like Wafergen Biosystems, Afymetrix, SBI, Luminex, Asper Biotech, Genentech San Francisco to name a few. The research has been supported as a course by more than 470 universities and gains international funding too.

Relevant Conferences:

International Conference on Nucleic Acids, August 04-05, 2016 New Orleans, USA; World Congress on Amino Acids and Proteins, December 08-09, 2016 Texas, USA; ; International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia, USA; 2^nd International Conference on Transcriptomics  September 12-14, 2016 Philadelphia, Pennysylvania USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA; Conference on Post-Transcriptional Gene Regulation (GRS), July 9-10, 2016 Vermont, USA; Basic Epigenetic Mechanisms in Cancer, November 8-11, 2015 Berlin, Germany, Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

 Track 12: Cancer Transcriptomics: Integrative & Computational Approaches

Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. The study involves the research in to the Bioinformatics and functional analysis of oncogenes, which refers to the gene that has the potential to cause cancer. In tumor cells, they are often mutated or expressed at high levels.

Cancer genome sequencing requires the development of new techniques utilizing Genomics and bioinformatics tools for target assessment, including both experimental protocols and data analysis algorithms, to enable a deeper understanding of complex biological systems. Databases for Cancer Research have been developed which primarily study the Mutations in Mitochondrial DNA and Cancer to come up with effective and informative databases.   It involves the development of Tools for integrative meta-analysis, 3c-based data integration and application of Networks and OMICS data, mathematical modeling and computational simulation techniques to the study of Integrative eqtl-based analyses, High performance genomics data visualization and Laboratory information management system to come up with Potential Diagnostic Applications. 

Computational Genomics research has grown after the increased research in Genomics with major universities like Iowa State University, University Of California, and The George Washington University Concentrating on the growing topic. The Bisti Consortium has even launched the NIH and Government Programs and Initiatives in Biomedical Informatics and Computational Biology (BICB) with a list of programs concentrating on Computational Biology Research.

Relevant Conferences:

Cancer Diagnostics Conference & Expo June 13-15, 2016 Rome, Italy; 11^th Asia-Pacific Oncologists Annual Meeting July 11-13, 2016 Kuala Lumpur, Malaysia; 12^th World Cancer Conference, September 26-28, 2016 London, UK; International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA; IMPAKT 2016 Breast Cancer Conference, May 12-14, 2016 Brussels, Belgium; Basic Epigenetic Mechanisms in Cancer, November 8-11, 2015 Berlin, Germany, Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 13: Epigenetics

Epigenetic modulation of gene expression is responsible for tissue specific and temporal changes across growth and development. The most widely studied of these epigenetic modifications is DNA methylation of 5-methylcytosine at CpG dinucleotides and histone modification. This DNA methylation can be caused by small factors like smoking tobaccos. Aberrations of DNA methylation are associated with a range of diseases, including imprinting disorders and cancer. Recent advances in technologies have made it possible to study the epigenetic changes associated with these diseases using robust genome-wide technologies including the Infinium HumanMethylation450 BeadChip (henceforward denoted the 450 k array; These intensities are then used to calculate DNA methylation levels, with advantageous throughput, cost, coverage and technical consistency. Gene silencing is also used for epigenetic regulation of gene expression. To study the modification on the genetic material of the cell called epigenome, Epigenomics comes into action. For all aspects of epigenetic principles and mechanisms in relation to human disease like diabetes and cancer, diagnosis and therapy Clinical Epigenetics is taken into consideration. It focuses on Clinical trials and research in disease model organisms. Currently, Pfizer is a major company carrying its research and development on Epigenetics.

Ulrich Mahlknecht is currently a Professor of medicine at the University of Heidelberg, and Head of the Department of Hematology/Oncology at St. Lukas Clinic in Solingen, Germany. His research focuses on novel targeted immunological and epigenetic concepts in the treatment of solid tumors and hematological malignancies.

Relevant Conferences:

2^nd International Conference on Transcriptomics, September 12-14, Philadelphia, USA; Clinical and Molecular Genetics Conference November 28-30, 2016 Chicago, USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA; Genetic and Protein Engineering Conference, November 14-16, 2016 Atlanta, USA; Genetic Counselling and Genomic Medicine Conference August 11-12, 2016 Birmingham, UK; Post-Transcriptional Gene Regulation(GRS), July 09-10, 2016 Vermont, USA; Basic Epigenetic Mechanisms in Cancer, November 8-11, 2015 Berlin, Germany, Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 14: Transcriptional Regulation & Attenuation

Transcriptional Regulation and Transcriptional Attenuation deals with Regulation of Transcription by which a cell regulates the conversion of DNA to RNA and attenuation which is a regulatory feature causing premature termination of transcription. There are various classes of attenuators according to the type of molecule which induces the change in RNA structure. It can be a Small-Molecule-Mediated Attenuation: Introduction to Riboswitches, in which Riboswitch sequences (in the mRNA leader transcript) bind micro and macro molecules, which cause a conformational change in the mRNA. The other type of attenuation includes Protein-Mediated Attenuation and Ribosome-Mediated Attenuation. This phenomenon of transcriptional attenuation is most prominent in the trp Operon found throughout Archaea and Bacteria.

Major Universities as of University of Southampton, University of Utah, MBL, University Of Colorado Boulder, University of Manitoba and University of Michigan have bought up courses dealing exclusively with Transcriptome Regulation and Attenuation encouraging and attracting specific research worldwide. The topic attracts major research funding too from INRA, NIH, Laboratory of Genome Regulation and Universitat Pompeu Fabra to name a few.

Relevant Conferences:

2^nd International Conference on Transcriptomics, September 12-14, Philadelphia, USA; Clinical and Molecular Genetics Conference November 28-30, 2016 Chicago, USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA; Genetic and Protein Engineering Conference, November 14-16, 2016 Atlanta, USA; Genetic Counselling and Genomic Medicine Conference August 11-12, 2016 Birmingham, UK; Post-Transcriptional Gene Regulation(GRS), July 09-10, 2016 Vermont, USA; Basic Epigenetic Mechanisms in Cancer, November 8-11, 2015 Berlin, Germany, Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 15: Clinical Applications & Related Disorders

There are many Clinical Application and Related Disorders with Transcriptomics. Clinical Transcriptomics focus on the understanding of the molecular basis of diseases through translational research. The key aspects include genome-wide gene expression analysis from human patient samples. These techniques can be used to detect transcriptome involved in Neurological Disorders employing technologies such as RNA-Seq, Cap Analysis of Gene Expression (CAGE) or small RNA sequencing. Neurological disorders like Huntington disease involves a DNA segment known as a CAG Repeats. It’s a tri-nucleotide repeats that appear multiple times in a row. A very novel technique called INsPeCT (INtegrative Platform for Cancer Transcriptomics), which allows users with basic computer skills to perform comprehensive in-silico analyses of microarray, ChIP-seq, and RNA-seq data.

Transcriptomics has a growing research in its clinical applications with major schools taking up it is a course like Karoliska Institutet, University of Bristol, University of Ferrara, Boston University School of Medicine and also being a part of major labs like SciLife Lab.

Relevant Transcriptomics Conferences | Biochemistry Conferences:

2^nd World Congress on Breast Cancer, September 19-21, 2016 Phoenix, USA; 2^nd Prostrate Cancer Conference,  August 22-23, 2016 Philadelphia, USA; 2^nd International Conference on Brain Disorders and Therapeutics October 26-28, 2016 Chicago, USA; 7^th International Conference on Biomarkers & Clinical Research ,December 05-07, 2016 Philadelphia, USA; 7^th Allergy Conference September 14-15, 2016 Amsterdam, Netherlands; Conference on Neurobiology of Brain Disorders ; 17^thWorld Conference on Lung Cancer, December 04-07, 2016 Vienna, Austria ;  Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 16: Transcriptome technologies Market

Innovation and discoveries in the field of Transcriptomics are opening many unlocked doors for the researchers and key vendors to concrete their ideas. Thus, a large belt of companies have created a Transcriptome technology market, making it more convenient to get the insight of the topic. Major Companies are providing more efficient and cost-effective way for the on-going researches. Through, transcriptomics meetings they can meet researchers from across the world and can share their technology globally.

Studies on Transcriptome analysis are providing a large platform for all the industries to expose their new launch. Companies involved in the manufacturing can be the most benefited one from this kind of transcriptomics expo.

Relevant Conferences:

2^nd International Conference on Transcriptomics, September 12-14, Philadelphia, USA; Clinical and Molecular Genetics Conference November 28-30, 2016 Chicago, USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA; Genetic and Protein Engineering Conference, November 14-16, 2016 Atlanta, USA; Genetic Counselling and Genomic Medicine Conference August 11-12, 2016 Birmingham, UK; Post-Transcriptional Gene Regulation(GRS), July 09-10, 2016 Vermont, USA; Basic Epigenetic Mechanisms in Cancer, November 8-11, 2015 Berlin, Germany, Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

Track 17: Transcriptomics Case Reports

Transcriptomics Case Reports deals with the study of mechanisms of preventing major disease, novel drug discovery, promoting health through organized efforts by involving different communities, societies, and organizations. It involves entire genome analysis to promote health of entire populations. It involves the total system and the eradication of particular disease like Huntington's disease, Breast Cancer etc. It mainly involves assessment and monitoring of the health of communities and populations at risk to identify health problems and priorities. Also, it monitors the formulation of public policies designed to solve identified local and national health problems and priorities. Lastly, it assures that all populations have access to appropriate and cost-effective care.

Relevant Conferences:

International Conference on Nucleic Acids, August 04-05, 2016 New Orleans, USA; World Congress on Amino Acids and Proteins, December 08-09, 2016 Texas, USA; International Conference on Next Generation Sequencing, November 17-18, 2016 Georgia, USA; 2^nd International Conference on Transcriptomics  September 12-14, 2016 Philadelphia, Pennysylvania USA; 5^th Cell and Gene Therapy Conference May 19-21, 2016 San Antonio, USA; EMBL Conference - Transcription and Chromatin, August 27-30, 2016 Heidelberg, Germany;  Chromatin Structure & Function, May 22-27, 2016 Les Diablerets, Switzerland;  Genetic Society of America , July 13-17, 2016, in Orlando, Florida : American Society of Human Genetics , October 18-22 , 2016 Vancouver, Canada, The RNA Society, June 28- July 2, 2016 Kyoto, Japan.

2^nd International Conference on Transcriptomics

About the Conference:

After the splendid success of the “International Conference on Transcriptomics” held at Orlando, USA during July 27-29, we welcome all the eminent researchers, students, scientists, CEO’s, directors, presenters and exhibitors from all over the world to Portland. We are delighted to invite you all to attend and register for the “2^nd International Conference on Transcriptomics”, which is going to be held in the month of September during 12-14, 2016 in Philadelphia , USA.

The organizing committee is gearing up for an exciting and informative conference program includingplenary lectures, symposia, workshops on a variety of topics, poster presentations and various programsfor participants from all over the world.

We invite you to join us at Transcriptomics-2016, where you will be sure to have a meaningful experience with scholars from around the world. All members of the Transcriptomics-2016 organizing committee look forward to meeting you in USA.

For more details please visit-http://transcriptomics.conferenceseries.com/

Importance & Scope:

Transcriptomics studies involve the collection and analysis of Transcriptomes of different types of cells or tissues of organism. It encourages researchers to understand transcriptional activity in disease caused. Transcriptomics research provides a profitable business opportunity to several pharmaceutical and biotech companies as these technologies have wide application areas such as drug discovery and research followed by clinical diagnosis of various disorders. With the arrival of advanced technological platforms, it creates a need for effective bioinformatics tools and services in order to manage and analyze huge amount of data released from these technologies.

Transcriptomics mainly focusses on the Universities, Institutes and Major Societies but even it also covers the big market in Transcriptome technology. So we can say that Transcriptomics is the topic to be focused equally on both: Academia as well as Business. It would be beneficial for all the researchers/students who really want their ideas to be implemented practically. Even those scientists who are willing to get some business for their research, this conference are a major platform. According to the theme, conference mainly focusses on Transcriptome analysis, Next Generation Sequencing and treatment of major sequence related disorders like Cancer & other Neurological Disorders. It also covers the same for microorganisms like Bacteria, Algae, Fungi and Plants.

Why Philadelphia?

Philadelphia the only World Heritage City in the United States. This  is the largest city in the Commonwealth of Pennsylvania and the fifth-most-populous in the United States.

The area's many universities and colleges make Philadelphia a top international study destination, as the city has evolved into an educational and economic hub.Philadelphia is the center of economic activity in Pennsylvania and is home to seven Fortune 1000 companies. With a gross domestic product of $388 billion, Philadelphia ranks ninth among world cities and fourth in the nation.

Philadelphia  is also home to a handful of biotechnology, pharmaceutical and medical device companies. ALS Biopharma, Areon Biosciences, Atrin Pharmaceuticals, Digna Biotech, Enantigen Therapeutics, MB Research Laboratories, One World Biotech, Impact Biologicals are just to name a few of the companies which are located in the state of Philadelphia. The city is also home to five schools of medicine: Drexel University College of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia College of Osteopathic Medicine, Temple University School of Medicine, and the Thomas Jefferson University. Hospitals, universities, and higher education research institutions in Philadelphia's four congressional districts received more than $252 million in National Institutes of Health grants in 2015.

The city is known for its arts, culture, and history, attracting over 39 million domestic tourists in 2013. The city is known for its hoagies, scrapple, soft pretzels, water ice, Irish potato candy, Tastykake, and is home to the cheesesteak. Philadelphia is home to many national historical sites that relate to the founding of the United States and welcomes around 40 million visitors every year from all around the world as tourists. From incredible historic sights with roots that date back to the beginning of our country's history like Independence National Historical Park, to places that house great works of art such as the Philadelphia Museum of Art, to incredible food venues, and gardens that will have you talking about their beauty for a long time afterwards, this city is loaded with incredible attractions. So holiday in Philadelphia, USA affords access to enjoy  great sites relating to the history and ancient culture of USA.

Conference Highlights:

·        Transcriptome analysis and Gene Expression

·        RNA Editing and RNA Interference: Interplay

·        Exploring the complexity of the Transcriptome

·        Next Generation Sequencing (NGS) Technologies

·        Disease Interrogation and Applications of RNA-Seq

·        Human Transcriptomics

·        Transcriptomics and Proteomics of Microorganisms

·        Transcriptomics and Proteomics of Plants

·        Single Cell Transcriptomics

·        Relation with OMICS Sciences: Genomics, Proteomics and Metabolomics

·        Expression Profiling

·        Cancer Transcriptomics: Integrative And Computational Approaches

·        Epigenetics

·        Transcriptional Regulation and Attenuation

·        Clinical Applications and Related Disorders

·        Transcriptome Technologies Market

Why to attend???

Meet your target audience with members from around the world focused on learning about Transcriptome analysis and research; this is your single best opportunity to reach the largest assemblage of participants from the scientific community. Conduct demonstrations,distribute information, meet with current and potential customers, and make a splash witha new product line, and receive name recognition at this 3-day event. World-renownedspeakers, the most recent techniques, tactics, and the newest updates in Transcriptomics growing market are hallmarks of this conference.

Be Part of it!

• This conference focusing on all the major aspects in the fields of Transcriptomics.

• It would be beneficial for all the students who ever willing to enter into research to the respective fields.

• As bringing the major research to the market and making it to utility are majorfocus for all the companies, this conference would be opportunity for the people in therespective fields.

Societies Associated with Transcriptomics Research:

1.      The Association of Bimolecular Resource Facilities (ABRF), Bethesda, MD, USA

2.      American Society of Gene and Cell Therapy, Milwaukee, Wisconsin, USA

3.      Triangle Chromatography Discussion Group, USA

4.      American Chemical Society

5.      American Society for Microbiology, USA

6.      RNA Society - Maryland, USA

7.      University of Nebraska Medical Centre, Omaha, Nebraska, USA

8.      US HUPO, Santa Fe, New Mexico, USA

9.      The Protein Society, USA

10. Society for Industrial Microbiology and Biotechnology, Fairfax, Virginia, USA

11. Federation of American Societies for Experimental Biology (FASEB), Maryland, USA

12. BioFlorida- Life Science Community

13. European Society of Human Genetics, Vienna, Austria

14. European Proteimcs Association (EuPA), UK

15. British Society for Proteome Research (BSPR), UK

16. Swiss Proteomics Society (SPS), Switzerland

17. Proteomics Society, India

Companies associated with Transcriptomics Research

1.      Affymetrix - Santa Clara, California USA

2.      Roche NimbleGen Inc. Madison, Wisconsin, United States

3.      SciGene Sunnyvale, California, United States

4.      Arrayit Corporation

5.      DNAmicroarray California, USA

6.      LC Sciences, Houston, TX, US

7.      SeqWright Genomic Services (a unit of GE health care)

Target Audience:

·        Professors

·        Scientists

·        Students

·        CEO, Directors of the companies.

·        Exhibitors

Target Audience:

Academia      50%

Industry        40%

Others          10%

Top Universities in USA:

Belhaven University, Orlando Campus.

Valencia College-Orlando.

University of Central Florida

Florida Agricultural and Mechanical University (Tallahassee). 

Florida Atlantic University (Boca Raton)

Florida Gulf Coast University (Ft. Myers)

Florida International University (Miami)

Florida State University (Tallahassee)

New College of Florida (Sarasota)

University of Florida (Gainesville)

University of North Florida (Jacksonville)

University of South Florida (Tampa)

The Genome Institute – St. Louis, Missouri

RNA Therapeutics Institute – Worcester, Massachusetts

Princeton University

Berkeley University

Yale University

The University of British Columbia

University of Maryland

University of Leeds

Case Western Reserve University

Arizona State University, Tempe

People associated with Transcriptomics Research:

As Transcriptomics is dealing with the complete range of RNA related content and so the total number of people associated are estimated on the basis of research going on Transcriptomics as well as related aspects such as Next generation sequencing, RNA-Seq, Transcriptome analysis, non-coding RNA etc.

Glance at Transcriptome Technology Market:

Total market share for major biotech companies has been analyzed. Among them are the companies who specifically focus on Transcriptome technology market

The major technologies employed for Transcriptome analysis comprises:

·        Microarrays

·        PCR

·        RNAi Gene Silencing Technology

·        NGS Technology
 

Products manufactured by the Companies related Transcriptomics Research and its Market Value:

Major companies are involved in the manufacturing and designing of Sequencing Platforms as well as technologies for the process. These technologies include:

·        Illumina (Solexa) sequencing by Illumina

·        Roche 454 sequencing by Hoffmann-La Roche

·        Ion torrent: Proton / PGM sequencing by Life technologies

·        SOLiD sequencing by Applied Biosysytems

Product based companies:

Affymetrix -Calculation of Revenue is on quarterly basis: For the second quarter of 2015, operating expenses were $49.1 million and the product revenue was $75.9 million 

Roche NimbleGen Inc - Innovator, manufacturer and supplier of a proprietary suite of DNA microarrays, instruments and services. Investment - 9 billion Swiss francs in R&D. Revenue from sales was of 47.5 billion Swiss francs.

SciGene - develops and commercializes genome analysis technologies in research and clinical laboratories. Revenue: $1M to $5M USD

Arrayit Corporation - is a leading life sciences company providing innovative products and services to empower scientists and clinicians to explore the human genome as well as the genomes of plants and animals. Revenue (annual) - $4.37 million

DNAmicroarrayCalifornia, USA – Product based company providing research tools for Therapeutics and Diagnostics in Genomic, Proteomic and Transcriptomics

LC Sciences - Global biotechnology company providing products and services to genomics, proteomics and Transcriptomics researchers across an array of markets for nucleic acid/protein analysis, biomarker-discovery and drug development.

SeqWright Genomic Services (a unit of GE health care): SeqWright Genomic Services is a Contract Research Organization (CRO) providing research products for molecular biology, to microarray, and next generation genomics.

Agilent now serves a $44 billion combined market that includes chemical, energy, pharmaceutical, food safety, environmental, forensics, life sciences research, clinical and diagnostics end markets.

PerkinElmer, Inc. combines innovative detection, imaging, laboratory services, and informatics solutions with knowledge and expertise to support the discovery of critical insights in diagnostics, life sciences, and environmental applications.
Total revenue-$2,247 million

References:

1. http://www.city-data.com/us-cities/The-South/Orlando-Economy.html

2. https://www.linkedin.com/

3. http://www.ncbi.nlm.nih.gov/pubmed

4. http://www.orlandoedc.com/News/biotech-life-science/

5. http://biopharmguy.com/links/state-fl.php

6. http://mybio.wikia.com/wiki/Microarray_companies

7. http://biopharmguy.com/links/company-by-name-south.php

8. http://www.bio.davidson.edu/projects/gcat/gsi/microarrays.html

9. http://en.wikipedia.org/wiki/List_of_biotechnology_companies

10. http://www.prnewswire.com/news-releases/rna-analysistranscriptomics-market-worth-37730-million-by-2019-277234001.html