Transcriptomics

Cancer Transcriptomics: Integrative and Computational Approaches

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Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. The study involves the research in to the Bioinformatics and functional analysis of oncogenes, which refers to the gene that has the potential to cause cancer. In tumor cells, they are often mutated or expressed at high levels.

Cancer genome sequencing requires the development of new techniques utilizing Genomics and bioinformatics tools for target assessment, including both experimental protocols and data analysis algorithms, to enable a deeper understanding of complex biological systems. Databases for Cancer Research have been developed which primarily study the Mutations in Mitochondrial DNA and Cancer to come up with effective and informative databases.   It involves the development of Tools for integrative meta-analysis, 3c-based data integration and application of Networks and OMICS data, mathematical modeling and computational simulation techniques to the study of Integrative eqtl-based analyses, High performance genomics data visualization and Laboratory information management system to come up with Potential Diagnostic Applications. 

Computational Genomics research has grown after the increased research in Genomics with major universities like Iowa State University, University Of California, and The George Washington University Concentrating on the growing topic. The Bisti Consortium has even launched the NIH and Government Programs and Initiatives in Biomedical Informatics and Computational Biology (BICB) with a list of programs concentrating on Computational Biology Research.