Transcriptomics

Transcriptional Regulation and Attenuation

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Transcriptional Regulation and Transcriptional Attenuation deals with Regulation of Transcription by which a cell regulates the conversion of DNA to RNA and attenuation which is a regulatory feature causing premature termination of transcription. There are various classes of attenuators according to the type of molecule which induces the change in RNA structure. It can be a Small-Molecule-Mediated Attenuation: Introduction to Riboswitches, in which Riboswitch sequences (in the mRNA leader transcript) bind micro and macro molecules, which cause a conformational change in the mRNA. The other type of attenuation includes Protein-Mediated Attenuation and Ribosome-Mediated Attenuation. This phenomenon of transcriptional attenuation is most prominent in the trp Operon found throughout Archaea and Bacteria.

Major Universities as of University of Southampton, University of Utah, MBL, University Of Colorado Boulder, University of Manitoba and University of Michigan have bought up courses dealing exclusively with Transcriptome Regulation and Attenuation encouraging and attracting specific research worldwide. The topic attracts major research funding too from INRA, NIH, Laboratory of Genome Regulation and Universitat Pompeu Fabra to name a few.